• Biochemistry

    What is Prion?

    Prion, an abnormal form of a normally harmless protein found in the brain that is responsible for a variety of fatal neurodegenerative diseases of animals, including humans, called transmissible spongiform encephalopathies. In the early 1980s American neurologist, Stanley B. Prusiner and colleagues identified the “proteinaceous infectious particle,” a name that was shortened to “prion” (pronounced “pree-on”). Prions can enter the brain through infection, or they can arise from mutations in the gene that encodes the protein. Once present in the brain prions multiplies by inducing benign proteins to refold into the abnormal shape. This mechanism is not fully understood, but another protein normally found in the body may also be…

  • Biology

    Father of Various Branches of Biology

    Father of Agronomy Peter – De- Cresenji Father of Agriculture Norman Borlaug Father of Anatomy Andreas Vesalius Father of Botany Theophrastus Father of Biology Aristotle Father of Bacteriology Antonie van Leeuwenhoek Robert Koch / Ferdinand Cohn / Louis Pasteur Father of Blood Groups Karl Landsteiner Father of Blood Circulation William Harvey Father of Cytology Robert Hooke Father of Endocrinology Thomas Addison Father of Evolution Charles Darwin Father of Genetics G. J. Mendel Father of Modern Medicine Hippocrates Father of Modern Physiology Wilhelm Wundt Father of Modern Biochemistry Carl Alexander Neuberg Father of Immunology Edward Jenner’s Father of Taxonomy Carl Linnaeus Father of Surgery Sushruta Father of Eugenics Francis Galton Father…

  • Biochemistry,  Q & A

    Q & A ON CELL RESPIRATION

    1. How do cells obtain the energy they need to function? Cells obtain energy for their metabolic reactions from breaking down organic molecules with a high energy content. This energy is mostly stored as ATP molecules. The process of obtaining energy in order to produce ATP molecules is called cellular respiration. 2. What compound is phosphorylated for ATP formation? What is the resulting compound when ATP releases energy? ATP, or adenosine triphosphate, is formed after the binding of one phosphate molecule (phosphorylation) to one ADP (adenosine diphosphate) molecule. This is a process that stores energy in the produced ATP molecule. When ATP provides energy to the cellular metabolism, it releases…

  • Biochemistry,  Q & A

    Q & A ON WATER AND MINERAL SALT

    Q1.  What is the approximate percentage (in mass) of water in the human body? Is this percentage expected to be larger in the adult or in the old individual?  Ans: Approximately 65% of the human individual mass is water. The brain, for example, has around 90% of water in mass, the muscles, 85%, and the bones have between 25% and 40% of water. Younger adult individuals have proportionally more water in mass than older individuals. Q2.  What are the main biological functions of water? Ans: Water is the fundamental solvent for chemical reactions of living beings; it is the main means of substance transportation in the cell and between cells…

  • Biochemistry,  Cell biology,  Genetics

    WHAT IS DNA?

    Deoxyribonucleic acid (DNA) is a molecule that carries most of the genetic instructions used in the development, functioning, and reproduction of all known living organisms and many viruses. DNA is a nucleic acid; alongside proteins and carbohydrates, nucleic acids compose the three major macromolecules essential for all known forms of life. DNA  stores instructions for making other large molecules, called proteins. These instructions are stored inside each of your cells, distributed among 46 long structures called chromosomes. These chromosomes are made up of thousands of shorter segments of DNA, called genes. Each gene stores the directions for making protein fragments, whole proteins, or multiple specific proteins. DNA is well-suited to…

  • Biochemistry,  Cell biology

    OXIDATIVE PHOSPHORYLATION, ELECTRON TRANSPORT CHAIN

    OXIDATIVE PHOSPHORYLATION It is the main source of energy of our cell. Takes place in Mitochondria. Movement of protons through inner mitochondrial membrane leads to ATP production DEFINITION Oxidative phosphorylation includes the coupling of the oxidation of NADH or FADH2 by the respiratory chain with the synthesis of ATP via gradient of protons across the inner mitochondrial membrane. ELECTRON TRANSPORT CHAIN An electron transport chain consists of a properly arranged & oriented set of electron carriers transporting electrons in a specific sequence from a reduced nicotinamide coenzyme (NADH) or a reduced flavin prosthetic group (FADH2) to molecular O2. The inner mitochondrial membrane carries an electron transport chain called the mitochondrial respiratory chain,…

  • Biology

    COENZYMES

    Enzymes may be simple proteins or complex enzymes. A complex enzyme contains a non-protein part, called a prosthetic group (co-enzymes). Coenzymes are heat stable low molecular weight organic compound. The combined form of protein and the co-enzyme are called as holo-enzyme. The heat labile or unstable part of the holo-enzyme is called as apo-enzyme. The apo-enzyme gives necessary three-dimensional structures required for the enzymatic chemical reaction. Co-enzymes are very essential for the biological activities of the enzyme. Co-enzymes combine loosely with apo-enzyme and are released easily by dialysis. Most of the co-enzymes are derivatives of vitamin B complex group of substance. One molecule of the co-enzyme with its enzyme is sufficient…

  • Biochemistry

    Krebs (Citric Acid) Cycle

    It is also known as TriCarboxylic Acid (TCA) cycle.  In prokaryotic cells, the citric acid cycle occurs in the cytoplasm; in eukaryotic cells, the citric acid cycle takes place in the matrix of the mitochondria. The cycle was first elucidated by scientist “Sir Hans Adolf Krebs” (1900 to 1981). He shared the Nobel Prize for physiology and Medicine in 1953 with Fritz Albert Lipmann, the father of ATP cycle. The process oxidises glucose derivatives, fatty acids and amino acids to carbon dioxide (CO2) through a series of enzyme controlled steps. The purpose of the Krebs Cycle is to collect (eight) high-energy electrons from these fuels by oxidising them, which are transported…

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